Clinical Research Directory

Inclusion Criteria: * Diagnosis of advanced/metastatic NSCLC * To be candidate to active treatment * Aged ≥ 18 anni (up to 75 years old) * To be sexually active in last 30 days before treatment start * Eastern Cooperative Oncology Group (ECOG) performance status 0-1 * Written informed consent Exclusion Criteria: * History of endocrine disorders, excepting for controlled hypothyroidism (surgical or non-surgical) treated with replacement levothyroxine since at least 2 years * Any cancer-related or medical condition that would interfere with the patient reported outcomes or laboratory assessment. Examples include, but are not limited to: * Cancer-related conditions that may preclude/undermine sexual activity (e.g. leptomeningeal carcinomatosis, pathological vertebral fractures, gonadic metastases, unstable spinal cord compression, uncontrolled neurological symptoms, surgical complications): * History of chronic liver disease or hormonal replacement therapy (e.g. ADT for prostatic cancer) * Participants who not adequately recovered from previous confirmed chemotherapy-induced gonadotoxicity (e.g. cisplatin) * Chronic use of drugs with known effect on male sexuality, including opiates, anxiolytics, antidepressants, mood stabilizers, beta blockers (e.g. atenolol) and high dose diuretics * Psychiatric or substance abuse disorder that would interfere with the participant's ability to cooperate with the requirements of the study * Major psychological disorder and/or high distress level that would interfere with sexual function and the participant's ability to cooperate with the requirements of the study