Clinical Research Directory

Inclusion Criteria: * Provision of informed consent prior to any study specific procedures; * Acute type A aortic dissection is confirmed by computed tomography angiography; * The symptoms onset within 2 weeks; * Patients are diagnosed with ATAAD, with a new diagnosis of malperfusion syndrome ,by meeting both of the following criteria: 1. Radiographic findings reveal occlusion of the corresponding arteries (including either coronary artery, either carotid artery, celiac trunk, superior mesenteric artery or either iliac artery); 2. Clinical features of end organ ischemia (altered consciousness, paralysis, melena, abdominal pain, tenderness to palpation, loss of sensory or motor function of the lower extremities) OR laboratory findings suggestive of end organ ischemia (elevated cardiac enzymes, lactate, myoglobin, or creatine kinase). Exclusion Criteria: * Age \<18 yr and \>80 yr; * Unstable condition with cardiac tamponade or aortic rupture on admission; * Multiple types of malperfusion syndrome on admission; * Bloody stools or melena on admission; * Bilaterally fixed dilated pupils, hemorrhagic infarction or herniation of brain on admission; * Cardiopulmonary arrest and required continuous uninterrupted cardiopulmonary resuscitation on admission; * Irreversible multiple organ failure on admission; * Life expectancy \< 1 year; * Patients and (or) their families refused surgery;