Clinical Research Directory

Inclusion Criteria: * Meets the diagnostic criteria for severe pneumonia； * Age≥18 years old and \< 80 years old； * Willing to sign informed consent for the course of the study； Exclusion Criteria: * Patients with intracranial hypertension, acute coronary syndrome, pleural fistula, pneumothorax, or subcutaneous emphysema; * Pregnant and lactating patients; * Severely hemodynamically unstable (an increase in vasopressors by more than 30% in the first 6 hours, or norepinephrine \>0.5mg/kg/min); * Those who do not consent to participate in this study；