Clinical Research Directory
Browse clinical research sites, groups, and studies.
Anesthesia Induction with the Target-controlled Infusion of Propofol in High-risk Patients
Sponsor: Acibadem University
Summary
The purpose of this study is to compare the risk of hypotension following induction of anesthesia in high-risk patients (American Society of Anesthesiologists risk scores III and IV) using target-controlled infusion (TCI) of propofol versus standard manual induction of anesthesia. Our previously published study compared TCI and manual induction of anesthesia in a general patient population and found that hypotension developed less with TCI induction. This study is a continuation of the other study and will be conducted in high-risk patients.
Official title: Does Induction of Anesthesia with Target-controlled Propofol Infusion Reduce the Risk of Post-induction Hypotension in High-risk Patients?
Key Details
Gender
All
Age Range
18 Years - 100 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2024-08-30
Completion Date
2025-06-30
Last Updated
2025-02-03
Healthy Volunteers
No
Conditions
Interventions
Manual anesthesia induction
In manual anesthesia induction, anesthetic agents are administered at a fixed dose and rate adjusted according to the patient's weight
Anesthesia induction with Target controlled infusions (TCI)
Target controlled infusion (TCI) system aims to reach the theoretically targeted blood or brain concentration of anesthetic agents based on the patient's age, weight, and height, with computer-assisted algorithms.
Hemodynamic monitoring with pressure recording analytical method (PRAM)
The pulse contour device MostCare (Vytech, Vygon, Padova, Italy) provides functional hemodynamic monitoring using the pressure recording analytical method.
Locations (1)
Acibadem Altunizade Hospital
Istanbul, Turkey (Türkiye)