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New Preclinical and Clinical Approaches to Mesothelioma
Sponsor: Marco Emilio Bianchi
Summary
This study protocol involves the coordination between UO1 (IRCCS San Raffaele Hospital) and UO2 (Istituto Nazionale Tumori di Napoli - IRCCS G. Pascale) to explore the role of HMGB1 and CXCR4 in cancer treatment and metastasis. UO1 focuses on the role of HMGB1 in inflammation, mesothelioma progression, and tissue repair, as well as developing, in future, possible HMGB1 inhibitors for cancer therapy. UO2 specializes in CXCR4's role in cancer, developing CXCR4 antagonists, and tracking CXCR4-dependent metastasis. The hypothesis is that targeting HMGB1 and CXCR4 pathways will inhibit tumor progression and metastasis, enhancing anti-tumor immunity and improving therapeutic outcomes in cancer.
Official title: New Preclinical and Clinical Approaches to Mesothelioma, an Archetypal Inflammatory Tumor
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
70
Start Date
2024-07-25
Completion Date
2027-01-25
Last Updated
2024-08-02
Healthy Volunteers
No
Conditions
Locations (2)
Istituto Nazionale Tumori IRCCS Fondazione G.Pascale
Naples, Campania, Italy
IRCCS San Raffaele
Milan, Lombardy, Italy