Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
RECRUITING
NCT06536179

New Preclinical and Clinical Approaches to Mesothelioma

Sponsor: Marco Emilio Bianchi

View on ClinicalTrials.gov

Summary

This study protocol involves the coordination between UO1 (IRCCS San Raffaele Hospital) and UO2 (Istituto Nazionale Tumori di Napoli - IRCCS G. Pascale) to explore the role of HMGB1 and CXCR4 in cancer treatment and metastasis. UO1 focuses on the role of HMGB1 in inflammation, mesothelioma progression, and tissue repair, as well as developing, in future, possible HMGB1 inhibitors for cancer therapy. UO2 specializes in CXCR4's role in cancer, developing CXCR4 antagonists, and tracking CXCR4-dependent metastasis. The hypothesis is that targeting HMGB1 and CXCR4 pathways will inhibit tumor progression and metastasis, enhancing anti-tumor immunity and improving therapeutic outcomes in cancer.

Official title: New Preclinical and Clinical Approaches to Mesothelioma, an Archetypal Inflammatory Tumor

Key Details

Gender

All

Age Range

Any - Any

Study Type

OBSERVATIONAL

Enrollment

70

Start Date

2024-07-25

Completion Date

2027-01-25

Last Updated

2024-08-02

Healthy Volunteers

No

Conditions

Locations (2)

Istituto Nazionale Tumori IRCCS Fondazione G.Pascale

Naples, Campania, Italy

IRCCS San Raffaele

Milan, Lombardy, Italy