Clinical Research Directory

Inclusion Criteria: In case of the healthy subject group: * Adult individuals, age \> 18 \<65 years * Male or postmenopauzal females * BMI \<25 * Ability to give informed consent In case of the MASLD/MASH group * Adult individuals, age \> 18 \<65 years * Male or postmenopauzal females * BMI \> 25 * Biopsy proven MASLD/MASH * Ability to give informed consent Exclusion Criteria: * History of sustained excess alcohol ingestion: daily consumption \>30g/day (3 drinks per day) for males and \>20 g/day (2 drinks per day) for females * Patients with diabetes * Bariatric surgery * Other forms of liver disease (e.g. Hepatitis B,C, Wilson disease, hemochromatosis) * Proton-pump inhibitor usage one year prior to study participation * GLP1, SGLT2i or insulin use * Antibiotic use for the past 3 months * Probiotic or symbiotic usage * Pregnant women * Chronic illness (including a known history of heart failure, renal failure (eGFR \<30 ml/min), pulmonary disease, gastrointestinal disorders, or hematologic diseases), or other inflammatory diseases * Active infection * Use of ascal, clopidogrel or other platelet inhibition * Smoking * Blood thinners * Heart failure