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Ketogenic Diet and Brain Response in Anorexia Nervosa
Sponsor: University of California, San Diego
Summary
This is a longitudinal study with an open design in weight recovered anorexia nervosa (wrAN) individuals. Healthy controls (HC) will also be assessed. Study participants will be carefully assessed and will have 18F-fluorodeoxyglucose (\[18F\]FDG) positron emission tomography (PET) scans for assessment of regional brain glucose uptake. The wrAN group will be compared to healthy controls. Participants in the wrAN group will then complete 14 weeks of therapeutic ketogenic diet (TKD). At the end of the TKD study, participants will have assessments and a second \[18F\]FDG and TMS/EEG scan. Study participants will be followed over six months after the intervention. This follow-up procedure will help determine whether symptom improvement will be stable or worsen in individuals who choose to continue or discontinue the TKD intervention. This will be a naturalistic follow-up.
Official title: Ketogenic Diet in Weight Recovered Anorexia Nervosa to Normalize Brain Metabolism and Persistent Eating Disorder Psychopathology
Key Details
Gender
All
Age Range
18 Years - 45 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2024-10-02
Completion Date
2030-01
Last Updated
2025-03-26
Healthy Volunteers
Yes
Conditions
Interventions
Therapeutic Ketogenic Diet (TKD)
2 week induction to establish ketosis followed by 12 weeks therapeutic ketogenic diet
Locations (1)
University of California San Diego
San Diego, California, United States