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RECRUITING
NCT06540703
NA

Ketogenic Diet and Brain Response in Anorexia Nervosa

Sponsor: University of California, San Diego

View on ClinicalTrials.gov

Summary

This is a longitudinal study with an open design in weight recovered anorexia nervosa (wrAN) individuals. Healthy controls (HC) will also be assessed. Study participants will be carefully assessed and will have 18F-fluorodeoxyglucose (\[18F\]FDG) positron emission tomography (PET) scans for assessment of regional brain glucose uptake. The wrAN group will be compared to healthy controls. Participants in the wrAN group will then complete 14 weeks of therapeutic ketogenic diet (TKD). At the end of the TKD study, participants will have assessments and a second \[18F\]FDG and TMS/EEG scan. Study participants will be followed over six months after the intervention. This follow-up procedure will help determine whether symptom improvement will be stable or worsen in individuals who choose to continue or discontinue the TKD intervention. This will be a naturalistic follow-up.

Official title: Ketogenic Diet in Weight Recovered Anorexia Nervosa to Normalize Brain Metabolism and Persistent Eating Disorder Psychopathology

Key Details

Gender

All

Age Range

18 Years - 45 Years

Study Type

INTERVENTIONAL

Enrollment

90

Start Date

2024-10-02

Completion Date

2030-01

Last Updated

2025-03-26

Healthy Volunteers

Yes

Interventions

DIETARY_SUPPLEMENT

Therapeutic Ketogenic Diet (TKD)

2 week induction to establish ketosis followed by 12 weeks therapeutic ketogenic diet

Locations (1)

University of California San Diego

San Diego, California, United States