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A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.
Sponsor: AstraZeneca
Summary
This is a Phase I/II study designed to evaluate if experimental T cell engaging antibody targeting CD20 AZD5492 is safe, tolerable and efficacious in participants with Relapsed or Refractory B-Cell Malignancies.
Official title: A Modular Phase I/II Open-label Dose Escalation and Dose Expansion Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With Relapsed or Refractory B-Cell Malignancies (TITANium)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
174
Start Date
2024-09-18
Completion Date
2028-02-14
Last Updated
2026-03-27
Healthy Volunteers
No
Conditions
Interventions
AZD5492
CD8/TCR based T-cell engaging antibody targeting CD20, which is administered subcutaneously
Locations (29)
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La Jolla, California, United States
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Boston, Massachusetts, United States
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Hackensack, New Jersey, United States
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New York, New York, United States
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New York, New York, United States
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Charlotte, North Carolina, United States
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Winston-Salem, North Carolina, United States
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Houston, Texas, United States
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Seattle, Washington, United States
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Melbourne, Australia
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Nedlands, Australia
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Calgary, Alberta, Canada
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Toronto, Ontario, Canada
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Montreal, Quebec, Canada
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Hangzhou, China
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Shanghai, China
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København Ø, Denmark
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Pessac, France
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Villejuif, France
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München, Germany
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Ulm, Germany
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Würzburg, Germany
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Bologna, Italy
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Milan, Italy
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Chūōku, Japan
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Kashiwa, Japan
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Barcelona, Spain
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L'Hospitalet de Llobregat, Spain
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Madrid, Spain