Clinical Research Directory

Inclusion Criteria: * ASCVD risk ≥5% and below 20% over the following 10 years as defined by the standard pooled cohort equations * No previous CAD event (inclusive of myocardial infarction, diagnosis of CAD, stroke) * Previously genotyped as part of a research study that enables recontact of participants * Receiving primary care at a participating institution. Exclusion Criteria: * Prior diagnosis of CAD: inclusive of prior myocardial infarction and revascularization (stent or coronary artery bypass grafting) * Currently treated with lipid-lowering therapy, including statins, ezetimibe, PCSK9 inhibitors, inclisiran, or bempedoic acid * Future use of statins contraindicated * Prior diagnosis of Cerebrovascular disease: Inclusive of history of ischemic stroke, transient ischaemic attack (TIA), carotid endarterectomy, carotid artery stenting * Prior diagnosis of Peripheral arterial disease: Inclusive of history of claudication, revascularization (stents or bypass) * Severe hypercholesterolemia (LDL-C ≥ 190 mg/dL)