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A Research Study Comparing How Well Different Doses of the Medicine NNC0487-0111 Lower Blood Sugar in People With Type 2 Diabetes
Sponsor: Novo Nordisk A/S
Summary
The study will look at how well different doses of a new medicine called NNC0487-0111 help lower the blood sugar and body weight in people with type 2 diabetes. NNC0487-0111 is a new medicine which cannot be prescribed by doctors but has previously been tested in humans. Participants will either get NNC0487-0111, which is given as tablets or as injections, or placebo. Which treatment the participant get is decided by chance.The study will last for about 43 weeks.
Official title: Safety and Efficacy of Once-weekly Subcutaneous and Once-daily Oral NNC0487-0111 in Participants With Type 2 Diabetes - a Dose Finding Study
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
448
Start Date
2024-08-07
Completion Date
2025-10-24
Last Updated
2026-10-02
Healthy Volunteers
No
Conditions
Interventions
NNC0487-0111 subcutanous
NNC0487-0111 administered subcutanously (under the skin)
Placebo (NNC0487-0111 subcutanous)
NNC0487-0111 placebo administered subcutanously (under the skin)
NNC0487-0111 oral
NNC0487-0111 administered orally (in the mouth)
Placebo (NNC0487-0111 oral)
NNC0487-0111 placebo administered orally (in the mouth)
Locations (137)
Uni of Alabama at Birmingham
Birmingham, Alabama, United States
Velocity Clin Research LA
Los Angeles, California, United States
Southern Cal Clinical Research
Santa Ana, California, United States
Chase Medical Research LLC
Waterbury, Connecticut, United States
Fleming Island Ctr for Clin Res
Fleming Island, Florida, United States
Encore Medical Research LLC
Hollywood, Florida, United States
South Broward Research LLC
Miramar, Florida, United States
Florida Inst For Clin Res
Orlando, Florida, United States
Florida Institute for Clinical research
Orlando, Florida, United States
Cedar-Crosse Research Center
Chicago, Illinois, United States
Cotton O'Neil Clinical Research Center
Topeka, Kansas, United States
Advanced Internal Medicine, PLLC
Paducah, Kentucky, United States
Medstar Research Institute_Hyattsville
Hyattsville, Maryland, United States
MD Medical Research
Oxon Hill, Maryland, United States
Brigham & Women's Hospital
Boston, Massachusetts, United States
ActivMed Practice & Research LLC
Methuen, Massachusetts, United States
Arcturus HC PLC Troy Med Res
Troy, Michigan, United States
Arcturus Healthcare, PLC
Troy, Michigan, United States
Clinical Research Professionals
Chesterfield, Missouri, United States
StudyMetrix Research LLC
City of Saint Peters, Missouri, United States
AMC Community Endocrinology
Albany, New York, United States
Centricity Rsrch MHCity Multi
Morehead City, North Carolina, United States
Piedmont Healthcare/Research
Statesville, North Carolina, United States
Lillestol Research LLC
Fargo, North Dakota, United States
Plains Clinical Research Center, LLC_Fargo
Fargo, North Dakota, United States
Alliance for Multispec Res
Norman, Oklahoma, United States
Jefferson Endocrinology Assocs
Philadelphia, Pennsylvania, United States
Preferred Primary Care Physicians_Pittsburgh
Pittsburgh, Pennsylvania, United States
Health Concepts
Rapid City, South Dakota, United States
Holston Medical Group
Kingsport, Tennessee, United States
Clinical Research Associates
Nashville, Tennessee, United States
MidState Endocrine Associates
Nashville, Tennessee, United States
Velocity Clinical Res-Dallas
Dallas, Texas, United States
Victorium Clinical Research
Houston, Texas, United States
Synergy Groups Medical
Houston, Texas, United States
PlanIt Research, PLLC
Houston, Texas, United States
Radiance Clinical Research
Lampasas, Texas, United States
Tekton Research
McKinney, Texas, United States
Hillcrest Family Health Center
Waco, Texas, United States
Individual Practice For Specialized Outpatient Medical Care Doctor Miglena Rizova Ltd.
Kyustendil, Bulgaria
IPSOMC Dr. Miglena Rizova Ltd.
Kyustendil, Bulgaria
UMHAT "Kaspela", Depart. Endocrinology and Metab. Diseases
Plovdiv, Bulgaria
UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic
Plovdiv, Bulgaria
DCC Sveti Georgi EOOD
Plovdiv, Bulgaria
Diagnostic-Consultative Centre "Sveti Georgi" Eood
Plovdiv, Bulgaria
Medical centre Regina Life Clinic EOOD
Sofia, Bulgaria
UMHAT "Aleksandrovska"
Sofia, Bulgaria
UMHAT Aleksandrovska EAD, Densitometry and Bone Metabolic Diseases
Sofia, Bulgaria
USHATE "Akad. Ivan Penchev" Second Clinic of Endocrinology
Sofia, Bulgaria
USHATE Akad. Ivan Penchev EAD, Second Clinic of Endocrinology
Sofia, Bulgaria
AIPSMC Dr. Artin Magardichyan EOOD
Varna, Bulgaria
Poliklinika Solmed
Zagreb, City of Zagreb, Croatia
Clinical Hospital Centre Rijeka_Endocrinology
Rijeka, Primorje-Gorski Kotar County, Croatia
KBC Rijeka, Endokrinologija
Rijeka, Primorje-Gorski Kotar County, Croatia
Opca bolnica Karlovac
Karlovac, Croatia
Specijalna bolnica Krapinske Toplice - Endokrinologija
Krapinske Toplice, Croatia
Specijalna Bolnica za medicinsku rehabilitaciju Krapinske Toplice_Endocrinology
Krapinske Toplice, Croatia
Klinicki bolnicki centar Osijek_Endocrinology
Osijek, Croatia
Klinicki bolnicki centar Osijek
Osijek, Croatia
Opca bolnica Varazdin_Endocrinology
Varaždin, Croatia
Opca bolnica Varazdin
Varaždin, Croatia
Zentrum fuer klinische Studien Suedbrandenburg GmbH
Elsterwerda, Germany
Zentrum für klinische Studien Südbrandenburg GmbH
Elsterwerda, Germany
InnoDiab Forschung GmbH
Essen, Germany
Wendisch - Dahl Hamburg - DZHW
Hamburg, Germany
Wendisch/Dahl Hamburg
Hamburg, Germany
Institut für Diabetesforschung GmbH Münster - Dr. med. Rose
Münster, Germany
RED-Institut für medizinische Forschung und Fortbildung GmbH
Oldenburg in Holstein, Germany
Iatriko Psychicou Private Clinic
Athens, Greece
U.G.H of Athens "Attikon"
Athens, Greece
"Laiko" General Hospital of Athens
Goudi/Athens, Greece
EUROMEDICA Gen Clinic The/ki, Endocrin,Metabolism,Diabetes
Thessaloniki, Greece
424 Military General Training Hospital - 2nd Department of Internal Medicine
Thessaloniki, Greece
424 Military General Training Hospital
Thessaloniki, Greece
"Thermi" Private Hosital
Thessaloniki, Greece
EUROMEDICA Gen Clinic The/ki, Endocrin,Metabolism,Diabetes
Thessaloniki, Greece
"Thermi" Private Hosital
Thessaloniki, Greece
Debreceni Egyetem
Debrecen, Hajdú-Bihar, Hungary
Bajcsy-Zsilinszky Kórház
Budapest, Hungary
MH Egészségügyi Központ
Budapest, Hungary
Debreceni Egyetem
Debrecen, Hungary
Debreceni Egyetem
Debrecen, Hungary
Debreceni Egyetem
Debrecen, Hungary
Békés Megyei Központi Kórház
Gyula, Hungary
Somogy Vármegyei Kaposi Mór Oktató Kórház
Kaposvár, Hungary
Somogy Vármegyei Kaposi Mór Oktató Kórház
Kaposvár, Hungary
Heiwadai Hospital_Internal Medicine
Miyazaki, Miyazaki, Japan
Heiwadai Hospital
Miyazaki, Miyazaki, Japan
TOSAKI Clinic for Diabetes and Endocrinology_Diabetes and Endocrinology
Aichi, Japan
Tokuyama clinic_Diabetic internal medicine
Chiba, Japan
Tokuyama clinic
Chiba, Japan
Akaicho Clinic
Chiba-shi, Chiba, Japan
Naka Kinen Clinic_Internal medicine
Ibaraki, Japan
Naka Kinen Clinic
Ibaraki, Japan
Tokyo-Eki Center-building Clinic_Internal Medicine
Tokyo, Japan
Tokyo-Eki Center-building Clinic
Tokyo, Japan
Fukuwa Clinic_Internal Medicine
Tokyo, Japan
Fukuwa Clinic
Tokyo, Japan
Niepubliczny Zaklad Opieki Zdrowotnej Przychodnia Specjalistyczna A Wittek H Rudzki Sp. j.
Ruda Śląska, Gornoslaskie, Poland
Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET
Krakow, Lesser Poland Voivodeship, Poland