Clinical Research Directory

Inclusion Criteria: 1. age between 18 and 80 years; 2. Glasgow Coma Scale score of less than 8 upon admission; 3. patients resuscitated after out-of-hospital cardiac arrest; and (4) patient or their legal representative has signed the informed consent form. Exclusion Criteria: 1. cardiac arrest caused by irreversible factors such as trauma or poisoning; 2. cardiac arrest due to terminal conditions like advanced cancer; 3. uncorrected persistent cardiogenic shock, defined as a systolic blood pressure below 90 mmHg despite treatment with fluid resuscitation, vasopressors, and inotropic agents; 4. pre-existing cerebrovascular disease or CT-confirmed intracerebral hemorrhage upon admission; 5. pre-arrest Cerebral Performance Category (CPC) score between 3 and 5; 6. bradycardia or sick sinus syndrome following the return of spontaneous circulation; 7. pre-existing coagulation disorders or severe bleeding tendencies; 8. pregnant or breastfeeding women, or women of childbearing age with elevated serum hCG levels; 9. presence of treatment limitations (such as refusal by the patient or legal representative to undergo advanced life support, including mechanical ventilation, chest compressions, or targeted temperature management); 10. determination by the principal investigator that the patient is unsuitable for the trial.