Clinical Research Directory

Inclusion Criteria: 1. Subjects aged 40-59 years old. 2. Normal levels of gonadotropins, testosterone, and serum prolactin. 3. No use of other traditional Chinese and Western medicines for oligoasthenoteratozoospermia treatment in the past 3 months. 4. Patients who can understand the clinical study and commit to complying with the study requirements and procedures. 5. Patients who have signed the informed consent form and are able to complete the study as per the trial protocol. Exclusion Criteria: 1. Organic lesions of the reproductive system; 2. Use of antibiotics in the two weeks prior to recruitment; 3. Sexual dysfunctions such as erectile dysfunction, ejaculatory abnormalities, preventing completion of sexual intercourse; 4. Genitourinary infections, such as Chlamydia or Mycoplasma infections; 5. Abnormal sex hormone levels; 6. Obesity (BMI greater than 28); 7. History of allergies to the probiotic preparations used in this study; 8. Severe cardiovascular or cerebrovascular diseases, liver or kidney dysfunction, hematologic disorders, psychiatric illnesses, or other severe comorbidities; 9. Use of medications in the past 3 months that may affect the trial; 10. According to the investigator's judgment, the subject's condition does not qualify them for participation in the study.