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RECRUITING
NCT06545331
PHASE1

Study of XB010 in Subjects With Solid Tumors

Sponsor: Exelixis

View on ClinicalTrials.gov

Summary

This is a FIH study is to evaluate the safety, tolerability, PK, immunogenicity, and preliminary antitumor activity of XB010 as a single agent and in combination with pembrolizumab in subjects with locally advanced or metastatic solid tumors for whom alternative therapies do not exist or available therapies are intolerable or no longer effective.

Official title: A Dose-Escalation and Expansion Study of XB010 as a Single Agent and Combination Therapy in Subjects With Locally Advanced or Metastatic Solid Tumors

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

INTERVENTIONAL

Enrollment

396

Start Date

2024-08-06

Completion Date

2027-10-20

Last Updated

2026-03-30

Healthy Volunteers

No

Conditions

Locally Advanced or Metastatic Solid TumorsEsophageal Squamous Cell CancerHead and Neck Squamous Cell CancerNSCLC (Non-small Cell Lung Cancer)Hormone-receptor-positive Breast CancerTriple Negative Breast Cancer (TNBC)

Interventions

DRUG

XB010

IV administration of XB010

DRUG

Pembrolizumab

IV administration of Pembrolizumab

Locations (19)

Exelixis Clinical Site #4

Irvine, California, United States

Exelixis Clinical Site #19

Los Angeles, California, United States

Exelixis Clinical Site #10

Washington D.C., District of Columbia, United States

Exelixis Clinical Site #18

Orlando, Florida, United States

Exelixis Clinical Site #12

Atlanta, Georgia, United States

Exelixis Clinical Site #15

Chicago, Illinois, United States

Exelixis Clinical Site #5

St Louis, Missouri, United States

Exelixis Clinical Site #3

Huntersville, North Carolina, United States

Exelixis Clinical Site #6

Oklahoma City, Oklahoma, United States

Exelixis Clinical Site #9

Nashville, Tennessee, United States

Exelixis Clinical Site #1

Austin, Texas, United States

Exelixis Clinical Site #7

Dallas, Texas, United States

Exelixis Clinical Site #8

Houston, Texas, United States

Exelixis Clinical Site #11

Fairfax, Virginia, United States

Exelixis Clinical Site #2

Fairfax, Virginia, United States

Exelixis Clinical Site #17

Leicester, England, United Kingdom

Exelixis Clinical Site #13

London, England, United Kingdom

Exelixis Clinical Site #16

London, England, United Kingdom

Exelixis Clinical Site #14

Manchester, England, United Kingdom