Clinical Research Directory

Inclusion Criteria: 1. Both male and female outpatients or patients at psychiatric daycare service 2. Age 18-60 years old at the time of screening 3. A diagnosis of schizophrenia, schizophreniform disorder, psychosis NOS, based on the DSM-5 criteria 4. With a Positive and Negative Syndrome Scale (PANSS), score \< 3 in all 3 positive symptoms (P1: delusion, P2: conceptual disorganization, P3: hallucination) and 2 general symptoms (G9: unusual thought, G5: mannerism and posturing) for at least 3 months 5. With a PANSS score \< 4 in all 3 negative symptoms (N1: blunted affect, N4: social withdrawal, N6: lack of spontaneity/flow in conversation) for at least 3 months 6. Currently receiving antipsychotic treatment at a fixed dose for at least 3 months, including long-acting injectable antipsychotic 7. No revised use of benzodiazepines, antidepressants, anticholinergics, or other concomitant medications during the past 3 months Exclusion Criteria: 1. A score of 5 or more on any of the 30 PANSS rating items at screening 2. Admission to the acute psychiatric unit during the past 6 months 3. A change in dose of current antipsychotic medication in recent 3 months 4. Concomitant use of mood stabilizers, such as lithium, valproic acid, or other anti-epileptic drugs 5. Mental retardation known as IQ below 70 prior to the diagnosis of schizophrenia 6. A history of pervasive mental disorder or bipolar disorder 7. A medical condition with significant cognitive sequelae 8. A history of substance dependence during the past 6 months 9. Currently in pregnancy or breastfeeding 10. A history of allergy to N-Acetylcysteine 11. Patient with phenylketonuria ( because the Actein Effervescent Tablet 600 mg/tab contains aspartame)