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Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)
Sponsor: University of Twente
Summary
The goal of this comparative effectiveness trial is to study electrographic status epilepticus (ESE) treatment in comatose patients after cardiac arrest. The main questions the trial aims to answer are: * Does ESE treatment improve outcome? * What is the impact of ESE treatment on healthcare costs? Participants in the the intervention group will receive standard care completed with anti-seizure treatment. The control group will receive standard care without anti-seizure treatment.
Official title: Treatment of ELectrographic STatus Epilepticus After Cardiopulmonary Resuscitation-2: Multicenter Randomised Clinical Trial and Health Economic Evaluation of Anti-seizure Treatment in Comatose Cardiac Arrest Patients With SE on Continuous EEG
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
150
Start Date
2025-04-10
Completion Date
2030-12
Last Updated
2025-05-16
Healthy Volunteers
No
Conditions
Interventions
anti-seizure medication + sedative agent(s)
Stepwise approach: 1. a single dose of a parenteral benzodiazepine (lorazepam, midazolam, or diazepam) and a first parenteral anti-seizure medication (levetiracetam, valproate, or lacosamide) 2. a second parenteral anti-seizure medication plus a first continuous parenteral sedative agent (midazolam or propofol) 3. a second continuous parenteral sedative agent (midazolam, propofol, or ketamine)
Locations (20)
Centre Hospitalier Universitaire Saint-Pierre
Brussels, Belgium
Hôpital Universitaire de Bruxelles
Brussels, Belgium
Universitair Ziekenhuis Brussel
Brussels, Belgium
Centre Hospitalier Universitaire Marie Curie
Charleroi, Belgium
Ziekenhuis Oost-Limburg
Genk, Belgium
Universitair Ziekenhuis Gent
Ghent, Belgium
Centre Hospitalier Chrétien - MontLégia
Liège, Belgium
Centre Hospitalier Universitaire Sart-Tilmant
Liège, Belgium
Amsterdam University Medical Center
Amsterdam, Netherlands
Rijnstate Hospital
Arnhem, Netherlands
Catharina Hospital
Eindhoven, Netherlands
Medical Spectrum Twente
Enschede, Netherlands
University Medical Center Groningen
Groningen, Netherlands
Leiden University Medical Center
Leiden, Netherlands
St. Antonius Hospital
Nieuwegein, Netherlands
Canisius Wilhelmina Hospital
Nijmegen, Netherlands
Radboud University Medical Center
Nijmegen, Netherlands
Erasmus University Medical Center
Rotterdam, Netherlands
Maasstad Hospital
Rotterdam, Netherlands
VieCuri Medical Center
Venlo, Netherlands