Clinical Research Directory
Browse clinical research sites, groups, and studies.
Efficacy of Trastuzumab Deruxtecan in Metastatic Breast Cancer with Different HER2 Expression Patterns
Sponsor: Sun Yat-sen University
Summary
The purpose of this observational study is to learn about the HER2 heterogeneity and its impact on benefit from trastuzumab deruxtecan in metastatic breast cancer. The main question it aims to answer is: \- Does the heterogeneity of HER2 expression level and spatial distribution in different tissues affect the efficacy of trastuzumab deruxtecan in metastatic breast cancer?
Official title: HER2 Heterogeneity and Its Impact on Benefit from Trastuzumab Deruxtecan in Metastatic Breast Cancer
Key Details
Gender
FEMALE
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
800
Start Date
2022-10-10
Completion Date
2025-01
Last Updated
2024-12-04
Healthy Volunteers
No
Conditions
Interventions
Trastuzumab Deruxtecan
The patients received Trastuzumab Deruxtecan at a dose of 5.4 mg/kg every 3 weeks until disease progression or unacceptable adverse effects occurred.
Locations (23)
Fujian Cancer Hospital, Fujian Medical University
Fuzhou, Fujian, China
The 10th Affiliated Hospital of Southern Medical University
Dongguan, Guangdong, China
The First People's Hospital of Foshan
Foshan, Guangdong, China
The Sixth Affiliated Hospital, School of Medicine, South China University of Technology.
Foshan, Guangdong, China
Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China
Guangdong Provincial Hospital of Chinese Medicine
Guangzhou, Guangdong, China
The Affiliated Cancer Hospital, Guangzhou Medical University
Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
The First Affiliated Hospital of Guangzhou University of Chinese Medicine
Guangzhou, Guangdong, China
Yuebei People's Hospital of Shantou University
Shaoguan, Guangdong, China
National Cancer Center Shenzhen Hospital
Shenzhen, Guangdong, China
Shenzhen People's Hospital
Shenzhen, Guangdong, China
Zhongshan City People's Hospital
Zhongshan, Guangdong, China
The Fifth Affiliated Hospital of Sun Yat-sen University
Zhuhai, Guangdong, China
Changde Hospital, Xiangya School of Medicine, Central South University
Changde, Hunan, China
Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University
Changsha, Hunan, China
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China
The First Affiliated Hospital, Hengyang Medical School, University of South China
Hengyang, Hunan, China
Affiliated Cancer Hospital of Inner Mongolia Medical University
Hohhot, Inner Mongolia, China
Xinhua Hospital Afliated to Shanghai Jiaotong University
Shanghai, Shanghai Municipality, China
The Second Affiliated Hospital, Zhejiang University School of Medicine
Hangzhou, Zhejiang, China
Cancer Hospital of Shantou University Medical College
The Affiliated Panyu Central Hospital, Guangzhou Medical University