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ElastoMRI Evaluation of Hepatic Metastases in Colorectal Cancer ( MetaIRM)
Sponsor: Assistance Publique - Hôpitaux de Paris
Summary
Currently, the tumor response of operated colorectal liver metastases is assessed by histology of the resection specimen.The histological data make it possible to define categories (responder, partial responder, non-responder). Overall survival (OS: overall survival) after surgery crucially depends on the response to neoadjuvant chemotherapy. Current criteria for predicting histological response in preoperative imaging are not satisfactory. The working hypothesis is that it is possible to better differentiate the tissue response to conventional chemotherapies and anti-angiogenics through MRI elastography by quantifying the changes in tissue mechanical properties induced by systemic treatments. The objectives is to evaluate the mechanical properties obtained by elasto MRI according to the systemic treatments envisaged: conventional chemotherapy such as Folfox or combined with targeted therapy
Official title: ElastoMRI Evaluation of Hepatic Metastases in Colorectal Cancer
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
50
Start Date
2024-08-10
Completion Date
2027-06-30
Last Updated
2024-08-13
Healthy Volunteers
No
Conditions
Interventions
an elastoMRI sequence
Addition of an MRI elasto sequence performed during MRI performed as part of the treatment