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Spastic Paraplegia - Centers of Excellence Research Network
Sponsor: Boston Children's Hospital
Summary
The Spastic Paraplegia - Centers of Excellence Research Network (SP-CERN) is a collaborative research consortium dedicated to advancing the understanding, diagnosis, and treatment of hereditary spastic paraplegia (HSP) and primary lateral sclerosis (PLS). Aims of the consortium are to a) perform natural history studies of HSP subtypes, b) discover and validate biomarkers and clinician- and patient-reported outcome measures, c) uncover HSP's molecular pathophysiology and develop rational therapeutic targets, and d) perform sufficiently powered clinical trials. The current pilot study is aimed at enrolling 100 individuals with hereditary spastic paraplegia type 4 (SPG4) or hereditary spastic paraplegia type 5A (SPG5A).
Official title: Spastic Paraplegia - Centers of Excellence Research Network (SP-CERN) - Natural History Study Pilot
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
100
Start Date
2024-06-04
Completion Date
2027-06-04
Last Updated
2026-03-18
Healthy Volunteers
No
Conditions
Locations (11)
University of Miami Miller School of Medicine
Miami, Florida, United States
University of Iowa Carver College of Medicine
Iowa City, Iowa, United States
Boston Children's Hospital
Boston, Massachusetts, United States
Massachusetts General Hospital
Boston, Massachusetts, United States
University of Michigan School of Medicine
Ann Arbor, Michigan, United States
Columbia University - Irving Medical Center
New York, New York, United States
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States
Scottish Rite for Children
Dallas, Texas, United States
Texas Children's Hospital
Houston, Texas, United States
Seattle Children's Hospital
Seattle, Washington, United States
University of Washington School of Medicine
Seattle, Washington, United States