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A Study of ZW191 in Participants With Solid Tumors
Sponsor: Zymeworks BC Inc.
Summary
The purpose of this study is to find out if ZW191 is safe and can treat participants with advanced cancers, including ovarian, endometrial, and non-small cell lung cancers.
Official title: A Phase 1, Open-label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Anti-tumor Activity of Ascending Doses of a Folate Receptor Alpha Antibody Drug Conjugate, ZW191, in Participants With Advanced Solid Tumors
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
145
Start Date
2024-10-30
Completion Date
2027-01
Last Updated
2026-04-09
Healthy Volunteers
No
Conditions
Interventions
ZW191
Administered intravenously
Locations (27)
Yale University
New Haven, Connecticut, United States
The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
Columbus, Ohio, United States
Stephenson Cancer Center
Oklahoma City, Oklahoma, United States
NEXT Oncology
San Antonio, Texas, United States
NEXT Virginia
Fairfax, Virginia, United States
Linear Clinical Research
Nedlands, Australia
Royal North Shore Hospital Northern Sydney Cancer Centre
St Leonards, Australia
National Cancer Center Hospital East
Kashiwa-shi, Japan
Saitama Medical University International Medical Center
Saitama, Japan
National Cancer Center Hospital
Tokyo, Japan
The Cancer Institute Hospital of JFCR
Tokyo, Japan
National University Health System (NUHS) - National University Cancer Institute Singapore (NCIS)
Singapore, Singapore
National Cancer Centre Singapore
Singapore, Singapore
Curie Oncology
Singapore, Singapore
National Cancer Center
Goyang-si, South Korea
Seoul National University Bundang Hospital
Seongnam-si, South Korea
Seoul National University Hospital
Seoul, South Korea
Severance Hospital, Yonsei University Health System
Seoul, South Korea
Asan Medical Center
Seoul, South Korea
Samsung Medical Center
Seoul, South Korea
Gangnam Severance Hospital
Seoul, South Korea
Hospital Universitari Vall d'Hebron
Barcelona, Spain
Hospital Universitario Reina Sofia
Córdoba, Spain
Clínica Universidad de Navarra
Madrid, Spain
NEXT Oncology Madrid
Madrid, Spain
Fundacion Instituto Valenciano de Oncologia (IVO)
Valencia, Spain
Hospital Clinico Universitario de Valencia
Valencia, Spain