Clinical Research Directory

Inclusion Criteria: * Patients over the age of 19. * Patients undergoing Endoscopic Sinus Surgery (ESS) * Patients with CRSwNP with moderate-severe asthma according to 2020 EPOS criteria: 1. Asthma confirmed with spirometry and assessment on the previous history of asthma (a methacholine challenge test and atopy testing to document the positive or negative history of asthma will be performed if there is no clinical record). Asthma severity based on GINA guidelines. 2. Presence of nasal polyps. This can be based on the formal exam at Baseline Visit or historical assessment. Exclusion Criteria: * Patients with current or past sinonasal or bronchial tumours * Subjects who have been treated with oral antibiotics in the past month prior to surgery * Subjects with known immunodeficiency * Subjects with known autoimmune disease * Subjects with other sinonasal diseases other than CRSwNP (e.g., cystic fibrosis, eosinophilic granulomatosis with polyangiitis, allergic fungal rhinosinusitis, invasive fungal sinusitis, fungal ball, dyskinetic cilia syndrome) * Prior lung transplants * Subjects with hypersensitivity; with allergy/intolerance to a monoclonal antibody or biologic * Prior use of dupilumab or other biologic medications (omalizumab. mepolizumab, reslizumab,etc) 6 months before enrollment. * Any condition that, in the opinion of the investigator, may interfere with the patient's ability to participate in the study per protocol. * Participation in an ongoing interventional or observational study using a biologic treatment. * Female participants who are pregnant or breastfeeding