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Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants
Sponsor: Insel Gruppe AG, University Hospital Bern
Summary
DO-IT is an international, prospective observational registry evaluating whether the administration of intravenous thrombolysis (IVT) is safe and improves functional outcome in ischemic stroke patients with recent direct oral anticoagulant (DOAC) intake. For this purpose, information on 2800 adult participants experiencing an acute ischemic stroke will be obtained at several high-volume international stroke centers and divided into three groups: IVT with recent DOACs intake (DOAC+IVT), and recent DOAC intake not receiving IVT (DOAC) as well as anonymized patients without DOAC receiving IVT. The patients are followed up for 90 days after the index event. treatment recommendations from the described observations. The investigators hypothesize that also more liberal decisions for IVT in patients with recent DOAC intake are not associated with an increased risk for symptomatic intracerebral hemorrhage (sICH) and result in better functional outcome at 3 month.
Official title: Safety and Efficacy of Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants: the DOAC - International Thrombolysis (DO-IT) Cohort Study
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
2800
Start Date
2024-01-01
Completion Date
2026-12-31
Last Updated
2024-08-16
Healthy Volunteers
No
Conditions
Interventions
Tenecteplase and Alteplase
The timepoints, dose, and type of IVT will be collected as well as any complications occuring.
Locations (33)
Medical University of Innsbruck
Innsbruck, Austria
Cliniques Universitaires Saint Luc
Brussels, Belgium
UZ Leuven
Leuven, Belgium
The University of British Columbia | Vancouver General Hospital
Vancouver, Canada
CHU Caen
Caen, France
Nordwest-Krankenhaus Sanderbusch
Sanderbusch, Germany
Universitäsklinikum Tübingen
Tübingen, Germany
Dept. of Medicine, University of Thessaly
Larissa, Thessaly, Greece
A.O.R.N. Antonio Cardarelli Hospital
Naples, Italy
Ospedali Riuniti Hospital
Palermo, Italy
Ospedale "Bufalini", Cesena
Perugia, Italy
AUSL-IRCCS di Reggio Emilia
Reggio Emilia, Italy
Akershus Hospital
Oslo, Norway
Hospital de Egas Moniz
Lisbon, Portugal
Clinical Centre of Serbia, University Hospital Belgrade
Belgrade, Serbia
National University Hospital
Singapore, Singapore
Ljubljana University Medical Centre
Ljubljana, Slovenia
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
Hospital Universitari de Bellvitge
Barcelona, Spain
Kantonsspital Aarau
Aarau, Switzerland
Unispital Basel
Basel, Switzerland
Inselspital Bern, University Hospital Bern
Bern, Switzerland
HFR Fribourg
Fribourg, Switzerland
University Hospital Geneva
Geneva, Switzerland
CHUV Lausanne
Lausanne, Switzerland
Kantonsspital Lucerne
Lucerne, Switzerland
EOC Lugano
Lugano, Switzerland
Hôpital Neuchâtelois
Neuchâtel, Switzerland
Kantonsspital St. Gallen
Sankt Gallen, Switzerland
Hirslanden Zurich
Zurich, Switzerland
University Hospital Zurich
Zurich, Switzerland
Imperial College London NHS Trust
London, United Kingdom
King'S College Hospital Nhs Foundation Trust
London, United Kingdom