Clinical Research Directory

Inclusion Criteria: * Clinical diagnosis of stenosis at the origin of the carotid artery with indications for neuro-interventional treatment (symptomatic stenosis \>50%; asymptomatic stenosis \>70%) * Aged 18 or above * With palpable brachial and femoral arteries * The patient or his/her agent understands the purpose and needs of this study and signs the informed consent Exclusion Criteria: * Symptomatic stenosis or occlusion of multiple vessels at the same time * Intravascular intervention for multiple vessel lesions at the same time * Ischemic stroke within the past 2 weeks * Any active bleeding, severe anaemia, or coagulation disorder. At least one of the following laboratory tests must be met: haemoglobin \< 10g/dL, or platelet count \< 100,000 /μ L, or unadjusted INR \>1.5, or PT exceeds the upper limit of normal by 1 minute or heparin-induced thrombocytopenia * A large-area cerebral infarction stroke on the same side with sequelae may affect the judgment of the study endpoint * A history of cerebral hemorrhage in the past six months * Any condition that may interfere with digital subtraction angiography (DSA) or cause unsafe percutaneous arterial access Participating in other clinical trials, in the research stage or follow-up stage * Contraindications to cerebral angiography, such as allergy to iodine contrast agents and renal insufficiency * Unable to understand or sign the informed consent form * Severe functional damage to important organs, assessed by clinical physicians to have high surgical risks and intolerant of interventional surgery * Baseline modified Rankin scale greater than or equal to 2 * Expected survival is less than 6 months