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Nitrous Oxide and EMOtional Cognition
Sponsor: University of Oxford
Summary
The goal of this study is to uncover the underlying neuropsychological mechanisms of nitrous oxide, which may be relevant to its reported antidepressant effects. In particular, the study is designed to determine whether nitrous oxide changes the way in which healthy volunteers aged 18-40 years remember negative autobiographical memories. The main question the study aims to answer is: • Does nitrous oxide interfere with the emotional aspects of negative autobiographical memories? Other neuropsychological effects will also be assessed (e.g., emotional processing, emotional memory, response inhibition, and cognitive flexibility). Researchers will compare ENTONOX (50% nitrous oxide: 50% oxygen) with medical air. Participants will: * Attend three research visits (screening, inhalation, follow-up) * Take part in a 30 minute inhalation session of ENTONOX or medical air * Complete a series of cognitive tasks * Finish a series of self-report questionnaires
Official title: Investigating the Neuropsychological Effects of Nitrous Oxide
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
88
Start Date
2024-07-10
Completion Date
2025-10-01
Last Updated
2025-07-31
Healthy Volunteers
Yes
Conditions
Interventions
Entonox
30 minute inhalation using demand valve and mouthpiece
Medical Air
30 minute inhalation using demand valve and mouthpiece
Locations (1)
Psychiatry Department
Oxford, United Kingdom