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Pectin Intervention Study and Long-term Follow-up in Lipid Transfer Proteins Allergic Patients
Sponsor: Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Summary
Pectins are dietary fibers that have shown a health effect on patients with food allergy, as they are capable of modifying the composition of gastrointestinal microbiota, and producing an immunomodulatory effect. Preliminary results by the investigators show that the intervention for 2 months with pectins produces an increase in tolerance to peach, and changes in the microbiota compared to the group of patients treated with placebo. In this project, the investigators aim to study these clinical effects and the involved mechanisms. Moreover, the long-term effect (clinical reactivity to nsLTP and immunomodulatory effect) of the dietary intervention will be prospectively evaluated 6 months after the intervention.
Official title: Analysis of the Clinical Efficacy and Immunomodulatory Effect of Pectin in LTP Allergic Patients Through a Placebo-controlled Intervention Study and Long-term Follow-up
Key Details
Gender
All
Age Range
18 Years - 60 Years
Study Type
INTERVENTIONAL
Enrollment
62
Start Date
2025-01-13
Completion Date
2026-11-30
Last Updated
2025-06-15
Healthy Volunteers
No
Conditions
Interventions
Apple pectin (DE 57%)
Dietary intervention with apple pectin. Participants will orally take the supplement once a day, after dissolving it in 100 ml of water, for 6 months.
Placebo
Dietary intervention with maltodextrin. Participants will orally take the placebo (maltodextrin) once a day, after dissolving it in 100ml of water, for 6 months.
Locations (1)
Hospital Regional Universitario de Málaga
Málaga, Málaga, Spain