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The Effect of Systematic Endurance Training in Treatment of Women With Lipedema
Sponsor: Norwegian University of Science and Technology
Summary
Lipedema is a chronic adipose tissue disorder that primarily affects women. The etiology remains unclear and involves abnormal buildup of fat mainly in the lower limbs. It causes physical and psychological morbidity, often with significant impact of daily life. Effective treatment options are still limited, primary involving conservative measures such as compression therapy. Regular endurance training is known to have positive effects on pain management in other disorders, as well as beneficial effects on obesity management. Thus, LipidEx aims to explore the potential of high-intensity interval training (HIIT) as a novel therapeutic option for women with lipedema. We will now perform a cross-over randomized controlled trial (RCT) exploring the effects of 12 weeks of HIIT compared to a control period of usual care. Primary outcomes include changes in pain, and secondary outcomes include changes in adipose tissue mass and quality of life. Exploratory outcomes include changes in inflammatory markers, metabolites, and lipoprotein subfractions in blood and adipose tissue.
Official title: The Effect of Systematic Endurance Training in Treatment of Women With Lipedema - The LipidEx Study
Key Details
Gender
FEMALE
Age Range
18 Years - 65 Years
Study Type
INTERVENTIONAL
Enrollment
62
Start Date
2025-09-01
Completion Date
2026-07-31
Last Updated
2025-12-05
Healthy Volunteers
No
Conditions
Interventions
High intensity endurance training
12 weeks of high intensity endurance training three times a week. Two of the weekly sessions are supervised.
Locations (1)
Institute for Circulation and Medical Imaging, NTNU
Trondheim, Norway