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RECRUITING
NCT06559033

Determine the Frequency of Variants in the GBA/PSAP Genes in Patients With MM or MGUS

Sponsor: University Hospital, Rouen

View on ClinicalTrials.gov

Summary

No effective specific treatment is currently available for the management of Multiple Myeloma (MM) and Monoclonal Gammopathy of Undetermined Significance (MGUS). A better understanding of the pathophysiological mechanisms would make it possible to propose treatments specifically targeting the deregulated pathways.

Official title: Determine the Frequency of Variants in the GBA/PSAP Genes in Patients With Multiple Myeloma (MM) or Monoclonal Gammopathy of Undetermined Significance (MGUS)

Key Details

Gender

All

Age Range

18 Years - Any

Study Type

OBSERVATIONAL

Enrollment

300

Start Date

2025-10-07

Completion Date

2027-04-01

Last Updated

2026-06-10

Healthy Volunteers

Yes

Interventions

BIOLOGICAL

Evaluation of the presence and number of mutated alleles of the GBA/PSAP genes in patients with MM or MGUS

Estimation of the frequency of variants in the PSAP/GBA genes in patients with MM or MGUS, then comparison with a reference frequency from databases such as the Exome Aggregation Consortium, the Exome Sequencing Project, the 1000 Genomes Project and the dbSNP.

Locations (2)

Centre Henri Becquerel

Rouen, France

University Rouen Hospital

Rouen, France