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Remote Ischemic Conditioning for Acute Ischemic Stroke Treated With Mechanical Thrombectomy（RECAST-MT）
Sponsor: Capital Medical University
Summary
For patients with acute ischemic stroke caused by large vessel occlusion, endovascular thrombectomy has been demonstrated to be the most effective therapy, as approximately 90% of the occluded vessels can be recanalized. However, less than 50% of patients could achieve functional independence, and over 15% died 90 days after stroke. Although the mismatch of successful recanalization with poor prognosis can be attributed to many factors, the infarct core formed during thrombectomy and reperfusion injury after thrombectomy may be among the most important and effective neuroprotective strategies urgently needed. Remote ischemic conditioning (RIC) is a noninvasive strategy in which one or more cycles of brief and transient limb ischemia confer protection against prolonged and severe ischemia in distant organs. In the transient focal cerebral ischemia-reperfusion model, the application of remote ischemic conditioning before reperfusion or both before and after reperfusion reduces reperfusion injuries and the final infarct size. Because patients with acute ischemic stroke who are treated with endovascular thrombectomy can achieve a high rate of recanalization after focal ischemia, this patient population is akin to the model of transient focal cerebral ischemia-reperfusion. Furthermore, a pilot study has determined the safety and feasibility of remote ischemic conditioning in patients undergoing endovascular thrombectomy. However, whether remote ischemic conditioning could provide clinical benefits to patients with acute ischemic stroke who are treated with endovascular thrombectomy urgently needs investigations. This study aims to investigate the safety and efficacy of remote ischemic conditioning in improving functional outcomes of patients with acute ischemic stroke treated with endovascular thrombectomy and explore the effect of treatment duration on the treatment outcome of remote ischemic conditioning.
Official title: Safety and Efficacy of Remote Ischemic Conditioning for Acute Ischemic Stroke Treated With Mechanical Thrombectomy (RECAST-MT): A Multicenter, Randomized, Controlled, Open-label, Blinded Endpoint Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
2105
Start Date
2024-09-23
Completion Date
2027-02
Last Updated
2025-12-10
Healthy Volunteers
No
Interventions
14-day remote ischemic conditioning
RIC is a noninvasive therapy performed by an electric auto-control device with a cuff placed on the upper arm. RIC procedures consist of five cycles of 5-min inflation (200 mmHg) and 5-min deflation of the cuff on the upper arm. The procedure will be performed once before endovascular thrombectomy and twice daily for 14 days post-thrombectomy.
30-day remote ischemic conditioning
RIC is a noninvasive therapy performed by an electric auto-control device with a cuff placed on the upper arm. RIC procedures consist of five cycles of 5-min inflation (200 mmHg) and 5-min deflation of the cuff on the upper arm. The procedure will be performed once before endovascular thrombectomy and twice daily for 30 days post-thrombectomy.
Endovascular thrombectomy
Endovascular thrombectomy procedures are performed according to the guidelines to recanalize the occluded large vessel safely.
Best medical management
Best medical management is prescribed at the discretion of the treating physicians according to the guidelines.
Locations (56)
Suzhou Municipal Hospital of Anhui Province
Suzhou, Anhui, China
Taihe County People's Hospital
Taihe Chengguanzhen, Anhui, China
Tongling People's Hospital
Tongling, Anhui, China
Beijing Luhe Hospital affiliated to Capital Medical University
Beijing, Beijing Municipality, China
Beijing Fangshan District First Hospital
Beijing, Beijing Municipality, China
Fujian Provincial Hospital
Fuzhou, Fujian, China
Zhangzhou Municipal Hospital of Fujian Province
Zhangzhou, Fujian, China
Shenzhen Second People's Hospital
Shenzhen, Guangdong, China
South China Hospital Affiliated to Shenzhen University
Shenzhen, Guangdong, China
The Second Nanning People's Hospital
Nanning, Guangxi, China
Cangzhou Central Hospital
Cangzhou, Hebei, China
Army Medical University Noncommissioned Officer School Affiliated Hospital
Shijiazhuang, Hebei, China
Hebei General Hospital
Shijiazhuang, Hebei, China
The Hongda Hospital of Jiamusi University
Jiamusi, Heilongjiang, China
Xunxian People's Hospital
Hebi, Henan, China
Jiaozuo Coal Industry Group Co., Ltd. Central Hospital
Jiaozuo, Henan, China
Luoyang Yanshi People's Hospital
Luoyang, Henan, China
Nanyang Central Hospital
Nanyang, Henan, China
Henan Province People's Hospital
Zhengzhou, Henan, China
Xihua county people's hospital
Zhoukou, Henan, China
Huanggang Central hospital
Huanggang, Hubei, China
Huangshi central hospital
Huangshi, Hubei, China
Jingmen Central hospital
Jingmen, Hubei, China
Jingmen People's Hospital
Jingmen, Hubei, China
First People's Hospital of Tianmen
Tianmen, Hubei, China
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, China
The Third People's Hospital of Hubei Province
Wuhan, Hubei, China
Yichang Central People's Hospital
Yichang, Hubei, China
the First People's Hospital of Changde
Changde, Hunan, China
The Third Xiangya Hospital of Central South University
Changsha, Hunan, China
the First People's Hospital of Chenzhou
Chenzhou, Hunan, China
The Central Hospital of Xiangtan
Xiangtan, Hunan, China
Inner Mongolia Autonomous Region People's Hospital
Hohhot, Inner Mongolia, China
The Fourth Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
Anshan Changda Hospital
Anshan, Liaoning, China
Dalian Central Hospital
Dalian, Liaoning, China
The First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China
Shengli Oilfield Central Hospital
Dongying, Shandong, China
Jinan Third People's Hospital
Jinan, Shandong, China
Liaocheng People's Hospital
Liaocheng, Shandong, China
Liaocheng Third People's Hospital
Liaocheng, Shandong, China
The People's Hospital of Gaotang
Liaocheng, Shandong, China
Feixian People's Hospital
Linyi, Shandong, China
Yeda Hospital
Yantai, Shandong, China
Mianyang third people's hospital
Mianyang, Sichuan, China
Ya 'an People's Hospital
Ya'an, Sichuan, China
The Second Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang, China
Yueqing People's Hospital
Yueqing, Zhejiang, China
Beijing Chao-Yang Hospital
Beijing, China
Aerospace Central Hospital
Beijing, China
Xuanwu Hospital, Capital Medical University
Beijing, China
Beijing Fengtai You'anmen Hospital
Beijing, China
Beijing Red Cross Emergency Medical Center
Beijing, China
Beijing Daxing District People's Hospital
Beijing, China
Chongqing University Fuling Hospital
Chongqing, China