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RECRUITING
NCT06559553
PHASE1/PHASE2

"Selinexor+Pegaspargase+Dexamethasone"in Ⅰ/Ⅱ NKTCL

Sponsor: Mingzhi Zhang

View on ClinicalTrials.gov

Summary

evaluate the efficacy and safety of "Selinexor+pegaspargase+dexamethasone" in early stage NK/ T-cell lymphoma

Official title: A Prospective Clinical Study of "Selinexor+Pegaspargase+Dexamethasone" in the Treatment of Stage Ⅰ/Ⅱ NK/ T-Cell Lymphoma

Key Details

Gender

All

Age Range

18 Years - 70 Years

Study Type

INTERVENTIONAL

Enrollment

50

Start Date

2024-09-01

Completion Date

2026-12-31

Last Updated

2025-07-14

Healthy Volunteers

No

Conditions

Interventions

DRUG

Selinexor+pegaspargase+dexamethasone

Nuclear export protein-1 is the main transporter protein for leucine-rich proteins to enter the cytoplasm from the nucleus through the nuclear pore complex, which is overexpressed in malignant tumor cells. Studies have shown that Selinexor inhibits the nuclear export of viral mRNA such as EBV, and has good therapeutic potential for NKTCL. Selinexor combined with pemaspartase, dexamethasone and sequential radiotherapy may be the golden choice for early NK/T cell lymphoma, improving the local control rate of the disease and improving the overall prognosis of NK/T cell lymphoma.

Locations (1)

Oncology Department of The First Affilliated Hospital of Zhengzhou University

Zhengzhou, Henan, China