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RECRUITING
NCT06559995
PHASE2/PHASE3

Effects of Ketone Supplementation on Alcohol Withdrawal and Brain Metabolism in Alcohol Use Disorder

Sponsor: University of Pennsylvania

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to learn the effects of ketone supplement compared to placebo on alcohol withdrawal symptoms during a 4 day alcohol withdrawal management treatment in adults with moderate to severe alcohol use disorder at the Hospital of the University of Pennsylvania, Cedar Detox Center.

Key Details

Gender

All

Age Range

18 Years - 65 Years

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2025-08-01

Completion Date

2027-12

Last Updated

2025-09-15

Healthy Volunteers

No

Interventions

DIETARY_SUPPLEMENT

ketone supplement "D-beta-hydroxybutryric acid and R-1,3 butanediol" 12g of ketones,

ketone supplement

DIAGNOSTIC_TEST

magnetic resonance imaging session

1.5 hour magnetic resonance imaging session

DIETARY_SUPPLEMENT

Placebo beverage

Placebo beverage, visually matched, three times a day before meals, by mouth for 4 days plus 1 dose on day 5 for magnetic resonance imaging session visit.

Locations (1)

Center for Studies of Addiction

Philadelphia, Pennsylvania, United States