Clinical Research Directory

Inclusion Criteria: * Diagnosis of left-sided (greater than 15 cm of disease but not beyond the splenic flexure) or extensive (extending beyond the splenic flexure) ulcerative colitis or IBD-U or colonic Crohn's disease involving at least 1/3 of the colon (defined as 2 segments of the remaining colon; segments include right colon, transverse colon, left colon and rectum). * Disease duration must meet one of the following criteria: 1. onset of symptoms of IBD at least 8 years prior 2. diagnosis of IBD at least 8 years prior 3. diagnosis of IBD for any duration if other risk factors for colon cancer are present including: concomitant diagnosis of primary sclerosing cholangitis, personal history of dysplasia, sessile serrated adenoma or right sided hyperplastic polyps greater than 10mm in diameter, or a family history of colon cancer in a first degree relative or two second degree relatives. * Scheduled to undergo colonoscopy as part of routine care * At least one indication for the index colonoscopy must be to perform dysplasia surveillance. Exclusion Criteria: * Any condition that the endoscopist feels is a contraindication to random biopsies * History of visible (high or low grade) dysplasia not completely removed * History of sessile serrated adenoma not completely removed * History of colorectal cancer * Any condition for which the endoscopist feels that pancolonic contrast or virtual chromoendoscopy is mandatory * Less than 2 segments of the remaining colon have ever been involved with IBD * Colonoscopy\* in the last 11 months unless the colonoscopy: 1. was determined by the endoscopist to be insufficient for dysplasia surveillance and, 2. did not include a diagnosis of dysplasia or sessile serrated adenoma. \*Does not include sigmoidoscopy * Inability to provide informed consent