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High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection
Sponsor: Shanghai Jiao Tong University School of Medicine
Summary
This study is a multicentra, prospective study. The enrolled patients are HP positive. They are diagnosed as HP positive by rapid urease test and/or 13C urea breath test. According to the declaration of Helsinki, 200 patients will be included in this study. After obtaining the written informed consent of the patients, HP culture and drug sensitivity test will be conducted on all the selected patients with the success rate, adverse reactions, compliance, antibiotic resistance of HP and its impact on HP eradication.
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
200
Start Date
2024-08-21
Completion Date
2026-08-30
Last Updated
2024-12-30
Healthy Volunteers
No
Conditions
Interventions
Vonoprazan
Potassium competitive acid blocker
Amoxicillin
Antibiotics for H. pylori eradication
Bismuth Potassium Citrate
Gastric mucosal protective drug with anti-H. pylori effect
Minocycline,Metronidazole
Antibiotics for H. pylori eradication
Locations (10)
Hebi People's Hospital
Hebi, Henan, China
Jiaozuo People's Hospital
Jiaozuo, Henan, China
Luoyang central Hospital
Luoyang, Henan, China
The first people's hospital of ping ding shan
Pingdingshan, Henan, China
Xuchang central Hospital
Xuchang, Henan, China
The Second Affiliated Hospital of Henan University of science and technology
Zhengzhou, Henan, China
The Third People's Hospital of Zhengzhou
Zhengzhou, Henan, China
Zhengzhou People's Hospital
Zhengzhou, Henan, China
Zhoukou Central Hospital
Zhoukou, Henan, China
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, Shanghai Municipality, China