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Searching for Novel Therapeutic Approaches in Migraine Patients Resistant to Treatments
Sponsor: IRCCS National Neurological Institute "C. Mondino" Foundation
Summary
Primary working hypothesis is that NON-responders to mAbs bear a dysfunction of the endocannabidiome system (eCBome), as suggested by pre-clinical and clinical data by our group. They will be identified as patients showing a reduction of monthly migraine days \< 50% after three months of treatment. The clinical, biochemical and neurofunctional impact of novel therapeutic approaches expected to interfere with eCBome will be evaluated in NON-responder patients
Official title: Unraveling the Spectrum of Migraine Resistant to Treatments: Searching for Novel Biological PHEnotypes and theRApeutic Approaches (SPHERA Project)
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
OBSERVATIONAL
Enrollment
45
Start Date
2023-05-10
Completion Date
2026-05
Last Updated
2024-08-20
Healthy Volunteers
Not specified
Interventions
Palmitoyl ethanolamide
PEA supplementation (600mg twice a day for three months)
Ketogenic diet
Diet characterized by the following percentages of macronutrients: 65% fat, 27% protein and 8% carbohydrates
Locations (1)
Headache Science & Neurorehabilitation Unit
Pavia, Italy