Clinical Research Directory

Inclusion Criteria: 1. Patients with pathologically diagnosed advanced ovarian cancer/pancreatic cancer who have failed at least 1 prior lines treatment, and tumor tissue samples were positive for mesothlin IHC staining; 2. According to the RECIST 1.1, there is measurable tumor lesions (non-lymph node lesion 10mm in length or lymph node lesion 15mm in diameter measured by CT or MRI, with scan layer thickness 5mm); 3. Eastern Cooperative Oncology Group (ECOG) score of 2 and satisfactory major organ functions; 4. Estimated life expectancy \>3 months; 5. Female patients of childbearing age must undergo a serum pregnancy test at screening and prior to pretreatment and the results must be negative, and are willing to use a very effective and reliable method of contraception within 1 year after the last study treatment. Exclusion Criteria: 1. Pregnant or lactating women; 2. Any uncontrollable active infection, including but not limited to active tuberculosis, HBV infection; 3. Patients who have a history of other mesothelin-targeting therapy; 4. Patients who have a history of autoimmune disease; 5. The investigator assessed that the patient was unable or unwilling to comply with the requirements of the study protocol.