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A Cohort Study of Hereditary Ovarian Cancer Risk Prediction Models and Pathogenesis Exploration
Sponsor: Peking University Third Hospital
Summary
The aim of this project is to establish a bidirectional multicenter cohort of hereditary ovarian cancer and to describe the clinicopathologic features of hereditary ovarian cancer patients in our country. The risk prediction model of ovarian cancer for Chinese was established by following-up analysis of clinical and pathological information, genetic test results and detailed family history, to predict the risk of cancer in first-degree relatives of carriers of pathogenic/suspected pathogenic mutations, and to guide the intervention management of high-risk population of cancer. The study will identify novel tumor-causing mutations/predisposing genes by gene sequencing in a special family with hereditary tumor.
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
1000
Start Date
2024-01-01
Completion Date
2026-12-31
Last Updated
2025-06-18
Healthy Volunteers
No
Conditions
Interventions
Suspective gene mutations and family history
To observe if the patients with suspective gene mutations or family history take higher risk of suffering from ovarian cancer.
Locations (1)
Peking University Third Hospital
Beijing, Beijing Municipality, China