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NCT06564688

To Explore the Functional Connectivity Pattern of Cortical Swallowing Network in the Oral Phase of Post-stroke Dysphagia Based on Dynamic Causal Modelling

Sponsor: Fujian University of Traditional Chinese Medicine

View on ClinicalTrials.gov

Summary

Swallowing activity in the oral phase is regulated by the cortical swallowing network, and the functional connectivity pattern of the cortical swallowing network is related to swallowing activity. The structural damage of the cortical swallowing network and abnormal activation of brain areas related to swallowing in post-stroke dysphagia affect swallowing activity. The recovery of dysphagia after stroke is related to the compensation of swallowing network in the contralateral hemisphere and different connectivity patterns of diseased brain areas, and the integrity of cortical swallowing network connectivity affects the sequence of oral swallowing activities. However, it is not clear how the functional connectivity patterns and interactions of brain regions of the cortical swallowing network related to oral swallowing activity change in patients with oral dysphagia after stroke.

Key Details

Gender

All

Age Range

18 Years - 80 Years

Study Type

OBSERVATIONAL

Enrollment

Start Date

2024-08-20

Completion Date

2025-07-01

Last Updated

2024-08-21

Healthy Volunteers

Yes

Conditions

Dysphagia After Stroke Cortical Swallowing Network Functional Magnetic Resonance Imaging Oral Phase Dynamic Causal Modelling

Interventions

DIAGNOSTIC_TEST

Swallowing function test

The oral function score assesses the oral functional performance of chewing in all participants. The Functional oral feeding Scale (FOIS) was used to assess the ability of all participants to eat. The standardized swallowing assessment (SSA) was used to assess the global swallowing function of all participants.

Inclusion Criteria: 1. Inclusion criteria of patients with post-stroke oral dysphagia: * Patients with dysphagia after first stroke, meeting the diagnostic criteria of stroke, and confirmed by brain CT or brain MRI; * Oral dysphagia caused by stroke; * FOIS level ≤ 5; WST level ≥3; * Those who can understand and carry out the simple instructions of the treatment staff and are willing to accept the examination and treatment; * Clear consciousness and stable vital signs; * Patients in the recovery stage with stroke course and dysphagia duration between 0 and 6 months; * Right-handed; * Voluntary participants with informed consent. 2. Inclusion criteria of patients without dysphagia after stroke: * Patients with first-ever stroke, meeting the diagnostic criteria of stroke, and confirmed by brain CT or brain MRI; * No dysphagia, FOIS level =7; WST level =1; * Those who can understand and carry out the simple instructions of the treatment staff and are willing to accept the examination and treatment; * Clear consciousness and stable vital signs; * Patients in the recovery stage with stroke duration between 0 and 6 months; * Right-handed; * Voluntary participants with informed consent. 3. Inclusion criteria of healthy control group: * Normal cognitive function and swallowing function, FOIS level =7; WST level =1; * Gender and age matched with patients with dysphagia in the oral phase after stroke; * Right-handed; * Voluntary participants with informed consent. Exclusion Criteria: * Dysphagia not caused by stroke or non-oral dysphagia; * History of cerebral trauma, stroke, brain tumor, cerebrovascular, intracranial infection, Parkinson's disease, epilepsy, or other neurological or psychiatric diseases; * Symptoms of severe aphasia, neglect, visual field defect and other cortical lesions; Patients with severe cognitive impairment or depression; * Taking or within 2 weeks of taking drugs that affect the nervous system or psychoses; * Patients with metal implants and/or spatial claustrophobia who are not suitable for MRI scanning; * Visual/hearing disorders affecting training and assessment; * Persons who are participating in other research trials that may influence the results of this study.