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Stem Cell Applications in Biliary Atresia Patients
Sponsor: Necmi Kadıoğlu Hospital
Summary
Recently, mesenchymal stem cell (MSC) transplantation has emerged as a promising treatment for liver cirrhosis in adults. Additionally, bone marrow-derived stem cell transplantation has shown success in treating children with biliary atresia (BA). This study aims to evaluate the efficacy of Umbilical Cord-Derived Mesenchymal Stem Cell (UC-MSC) therapy in BA through a multicentric randomized controlled trial.
Official title: Umbilical Cord Derived Mesenchymal Stem Cell (UC-MSC) Transplantation in Infants with Biliary Atresia: a Prospective Randomized Controlled Trial
Key Details
Gender
All
Age Range
2 Months - 18 Years
Study Type
INTERVENTIONAL
Enrollment
64
Start Date
2024-06-01
Completion Date
2026-06-01
Last Updated
2024-09-19
Healthy Volunteers
No
Conditions
Interventions
Stem Cell
UC-MSC transplantation will be administered twice to each patient in the study group via the hepatic artery: the first transplantation will be performed post-surgery at the beginning, and the second one will be performed 6 months later, with a dose of 1 million UC-MSC/kg.
Control
In this group, UC-MSC will not be administered. This group serves as a passive control. The standard treatments that are routinely provided to these patients will continue to be administered.
Locations (1)
Esenyurt State Hospital
Istanbul, Istanbul, Turkey (Türkiye)