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CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs
Sponsor: University of Florida
Summary
Pilot pragmatic trial using an implementation science approach to determine the feasibility of a CYP2D6-guided opioid prescribing for patients undergoing elective VHRs compared to usual care. Assess the efficacy (PROMIS Pain Intensity and Hernia-Related QOL) of a CYP2D6-guided opioid prescribing approach for patients undergoing elective VHRs.
Official title: Feasibility and Efficacy of CYP2D6 Genotype-guided Management of Opioid Analgesics in Patients Undergoing Elective Ventral Hernia Repairs: A Pilot Pragmatic Trial
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
INTERVENTIONAL
Enrollment
100
Start Date
2025-01-29
Completion Date
2026-07
Last Updated
2026-01-08
Healthy Volunteers
No
Conditions
Interventions
Opioid pain medication prescribed based on CYP2D6 genotype testing PLUS Acetaminophen and Gabapentin
CYP2D6 genotype testing for assessment of medication metabolism to guide prescription of postoperative pain medication
Acetaminophen and Gabapentin: standard postoperative pain medications
Participants will receive standard postoperative pain medications
Locations (1)
University of Florida Jacksonville
Jacksonville, Florida, United States