Clinical Research Directory

Inclusion Criteria: * Aged 18-25 at time of recruitment * Body Mass Index (18.5 - 29.9 kg) : Healthy - Overweight * Stress score of 15≤ - ≥25 (DASS) * Willing and with capacity to give informed consent to participate at time of recruitment * Speak and comprehend English to a good standard * In good general health * Willing to provide stool, urine and blood (8mL) sample during intervention * Willing to attend 4 visits to Southampton General Hospital Clinical Research Facility over 10-11 weeks Exclusion Criteria: * Consuming ≥ 14 units of alcohol/week (6 x 175 mL of wine, 6 pints of 4% beer) * Learning or behavioural difficulties (assessed on individual basis) * Planning a pregnancy in the next 6 months, pregnant, lactating or had a recent birth ≥6 months * Currently smoking or using e-cigarette, vape * Vulnerable adults (with self reported sever or very severe stress score (DASS) * Unwilling to suspend existing probiotic / prebiotic supplementation (with additional 4 weeks washout) before starting study. Medical exclusions: * Actively involved in therapy or psychiatric intervention of a diagnosed mental health condition * Prescribed psychotropic medication (Antidepressants, Monoamine Oxidase Inhibitors (MAOI's), Antipsychotics, sleeping pills, mood stabilisers etc) * Allergic to milk, soy, corn, penicillin or fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPS) * Currently prescribed laxatives, enemas, anti-coagulants or painkillers * Existing medical condition: cancer, hepatobiliary surgery, diabetes or diagnosed gastrointestinal diseases (irritable bowel disease, ulcerative colitis) * Involved in a recent pharmacology/psychological intervention, last 6 months * Recent antibiotic prescription, last 6 months