Clinical Research Directory

Inclusion Criteria: * ALS patients, ambulant and hospitalized * Able to give informed consent * Diagnosed with ALS or probable ALS according to the existing revision of the El Escorial Criteria 21,22. * Patients with a peripheral neuromuscular disease, ambulant and hospitalized * Able to give informed consent * Diagnosed with a peripheral neuromuscular disease, that does not affect CNS, including but not limited to Myasthenia Gravis and polyneuropathy * Healthy controls * Able to give informed consent * Age and gender matched to ALS patients Exclusion Criteria: * All Participants * Other severe medical, neurological, or psychiatric disorders * Visual impairment to an extent that interferes with the ability to perform of the test * Severe motor or cognitive deficits, to the extent that the test-task cannot be performed * Alcohol or drug abuse to an extent the interferes with task performance * Patients with a peripheral neuromuscular disease ● Familial predisposition to ALS * Healthy controls * Familial predisposition to ALS (first degree relatives) * Medical treatment that affects the central nervous system (e.g., antidepressants)