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Leucine Supplementation Strategies to Enhance Muscle Anabolic Responses in Older Age
Sponsor: University of Nottingham
Summary
Sarcopenia describes the progressive decline of muscle mass and strength with advancing age and is associated with increased frailty and morbidity, however we do not currently have an effective treatment. Protein feeding and exercise is known to increase muscle mass, but aged muscle shows a lower response to these stimuli leading to muscle loss over time. We do know that ingesting leucine, a building block of protein, can overcome this reduced response to protein feeding and exercise leading to increased muscle mass in older people. However, we do not understand when the optimum time to ingest leucine is to maximise muscle mass after exercise in older people. In this study we will examine the effect of feeding leucine after exercise either with a meal or between meals.
Key Details
Gender
MALE
Age Range
65 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
10
Start Date
2024-08-05
Completion Date
2026-08-05
Last Updated
2024-08-23
Healthy Volunteers
Yes
Conditions
Interventions
Leucine
Leucine is a dietary supplement that can be easily purchased over the counter at health food stores. It is an essential amino acid and is involved in stimulate muscle protein synthesis.
Locations (1)
University of Nottingham
Nottingham, Nottinghamshire, United Kingdom