Clinical Research Directory

Inclusion Criteria: * Diagnostic of Autistic Spectrum Disorders (ASD). * History of gastrointestinal (GI) disorders, recurrent diarrhea, during the past 6 months. * Children attending learning or therapy centers or schools. * Age between 5 and 12 years of age. * Children whose parents or guardians consent their participation in the study. * Children who can provide the required biological samples, and their guardians must provide the necessary information to complete the established instruments. * The parents or guardians of the children must sign the informed consent form in order to be part of the study. Exclusion Criteria: * Use of antibiotics, systemic steroids or antifungal medication during the last 15 days prior to fecal sample collection. * Acute gastrointestinal, respiratory or febrile processes. * Severe chronic comorbidities such as cancer, immunosuppression, obstructive respiratory disorders, Crohn's disease, ulcerative colitis, among others, at the discretion of the investigators. * Probiotics consumption in the last three months prior to study enrollment. * History of allergy or hypersensitivity to Saccharomyces boulardii or its components, or allergy to yeasts. * Contraindication and special warning to Saccharomyces boulardii according to the technical Data Sheets, including central venous catheter carriers. * Simultaneous participation in clinical studies, or in exclusion periods of a previous clinical study.