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Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat
Sponsor: Jens Titze
Summary
The study aims to provide quantitative facts on the pathophysiological changes in tissue Na+ content during Na+/K+ redistribution disorders in patients with PA in response to standard therapy. The investigators hypothesize that patients with primary aldosteronism have excessive Na+ storage in the muscle, which can now be quantified non-invasively using 23NaMRI. In analogy to the role of HbA1c as a metabolic long-term marker in diabetes, the quantifiable changes in muscle Na+ content may deliver the data evidence necessary to justify and conduct randomized diagnostic endpoint outcome trials in the future, with the ultimate aim to improve PA detection rate and treatment.
Official title: Tissue Sodium Quantification in Patients With Primary Aldosteronism
Key Details
Gender
All
Age Range
21 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
80
Start Date
2023-12-27
Completion Date
2026-08-31
Last Updated
2025-06-06
Healthy Volunteers
No
Interventions
23NaMRI Scan
23NaMRI, a non-invasive detection and quantification of hidden tissue Na+ stores in humans.
Potassium Chloride (KCl)
K+ supplementation intervention is given participants as part of their standard care. In this trial the K+ supplementation dosage is standardized and adjusted based on blood K+ level
Locations (4)
Singapore General Hospital
Singapore, Singapore
Duke NUS Medical School
Singapore, Singapore
Changi General Hospital
Singapore, Singapore
Sengkang General Hospital
Singapore, Singapore