Clinical Research Directory
Browse clinical research sites, groups, and studies.
Colistin Monotherapy vs Colsitin-fosfomycine in CRAB Infection
Sponsor: Chiang Mai University
Summary
The goal of this clinical trial is to evaluate the efficacy of colistin compared with colistin plus fosfomycin against carbapenem-resistant Acinetobacter baumanii infection in Thailand. The main questions it aims to answer the following main questions: 1. Which group has better clinical response at end of treatment 2. Which group has better clinical response at 72 hours and micrological cure at 72 hours and at end of treatment
Official title: Efficacy of Colistin Monotherapy Versus Colistin Combined With Fosfomycin Against Carbapenem-Resistant Acinetobacter Baumannii Infections
Key Details
Gender
All
Age Range
20 Years - Any
Study Type
INTERVENTIONAL
Enrollment
188
Start Date
2023-04-01
Completion Date
2025-07
Last Updated
2024-08-26
Healthy Volunteers
No
Interventions
Colistin Sodium Methanesulfonate
Intravenous colistin (colistinmethate soidum) 5 mg/kg/day intravenous (dosage will be adjusted according to creatinine clearance). The duration of treatment ranges from 10 to 14 days, depending on the site of infection and clinical responsiveness.
Colistin Sodium Methanesulfonate plus Fosfomycin
Intravenous colistin(dosage is same as colistin group) plus intravenous fosfomycin(dosage will be adjusted according to MIC and creatinine clearance). The duration of treatment ranges from 10 to 14 days, depending on the site of infection and clinical responsiveness.
Locations (1)
Faculty of medicine, Chiang Mai university
Chiang Mai, Thailand