Clinical Research Directory

Inclusion Criteria: * Patients with at least 3 month-course of symptomatic restless leg syndrome * Must meet International Restless Legs Syndrome Study Group (IRLSSG) criteria of at least mild symptoms. * Age \> 18 years, including both males and females * Patient provides informed consent Exclusion Criteria: * Previous operative procedure for treatment of RLS; * Current use of TENS (transcutaneous electrical nerve stimulation or plasma exchange; * Allergy to Cannabidiol (CBD) Cannabidiolic acid (CBDa), or any other ingredient contained in the topical cream; * Pregnant participants (participants who have the potential for being pregnant will sign a waiver), or breast feeding; * History of recreational substance abuse, fibromyalgia, Chronic Regional Pain Syndrome (CRPS), psychiatric history including but not limited to schizoaffective disorder, bipolar disorder, chronic depression, and suicidal ideation; * Conditions affecting capacity and adherence to study regimen including but not limited to dementia/delirium, Alzheimer's, Down's syndrome; * A need for elective surgery involving preoperative or postoperative analgesics or anesthetics during the study period; * No recent cannabinoid use in the last 2 months, and no use during the study.