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Quantification of Myocardial Fibrosis in Aortis Stenosis
Sponsor: Norwegian University of Science and Technology
Summary
This study is a long term follow-up of patients that were included as part of a previous study (NCT03422770), where patients with aortic stenosis and healthy controls went through echocardiography, cardiac MRI, long-term ECG-recording, blood tests and quality of life assessment. Echocardiography included high frame ultrasound for detection of natural mechanical waves, and the measured speed of these waves were used as a marker of the extent of myocardial fibrosis. Up to five years have now passed since inclusion at baseline, and a proportion of the patients in the cohort have undergone aortic valve replacement at some point. In this study, the investigators will repeat the cardiac imaging (echocardiography and cardiac MRI), ECG and blood test, to assess long-term changes in myocardial fibrosis in aortic stenosis patients.
Official title: Myocardial Fibrosis With High Frame Rate Echocardiography in Patients With Aortic Stenosis - A Follow-up Study
Key Details
Gender
All
Age Range
18 Years - 90 Years
Study Type
OBSERVATIONAL
Enrollment
70
Start Date
2025-01-21
Completion Date
2026-04-15
Last Updated
2025-08-07
Healthy Volunteers
Not specified
Conditions
Interventions
High frame rate echocardiography
Conventional transthoracic echocardiography will be performed, with added 3D-imaging and acquisitions with high frame rate. The data from these patients will be anonymized and transferred for post-hoc analysis in dedicated computer software (GE Vingmed, EchoPac 2.6) and in validated machine learning algorithms.
MRI
Cardiac MRI will be performed. In all patients without contraindications, a gadolinium-based contrast agent will be given.
Blood test
Conventional brachial venous blood samples will be drawn. Hematocrit value {in %} will be used to calculate CMR-derived exttracellular volume (ECV)
ECG and Holter-ECG
ECG/Holter-ECG will be performed, and the findings will be related to the imaging findings.
6 min walking test
6 MWT will be performed, and the findings will be related to findings from CMRI/echocardiography.
Locations (1)
St. Olavs Hosptial
Trondheim, Trøndelag, Norway