Clinical Research Directory

Inclusion Criteria: * Threatened previable prelabor with intact membranes between 18weeks of gestation +0/7 and 23 weeks of gestation 6/7 SA defined on endovaginal ultrasound by a short cervix ≤10 mm, and/or protrusion of the membranes on speculum examination. * Maternal age \>18 years * Affiliated with social security * Correct understanding of the French language * Singleton pregnancy * Foetus alive at time of inclusion * Absence of regular and painful uterine contractions Exclusion Criteria: * Premature labor defined by regular, painful uterine contractions and a short cervix * Protected person (patient under guardianship/curatorship/or legal protection) * Multiple pregnancies * Premature rupture of membranes * Acute chorioamnionitis * Contraindication to protocol antibiotics * Chromosomal abnormality, congenital malformation * Patients who received antibiotics before randomization, or requiring antibiotics for another indication (chorioamnionitis, pyelonephritis, etc.) * Participation in another research (Specify the category: RIPH, EC, IC, etc.) or being in the exclusion period following previous research involving humans, if applicable * Patient under AME (if no exemption from affiliation)