Clinical Research Directory
Browse clinical research sites, groups, and studies.
Histiocytosis in Injecting Drug Users
Sponsor: Tampere University Hospital
Summary
The goal of this observational study is to describe a new disease condition of histiocytosis related to injecting drug use, its preconditions, symptoms, signs, findings, and prognosis in a detailed and systematic patient series in one referral center. The main question\[s\] it aims to answer are: * to find specific histologic features in different tissues to help the differential diagnosis from other histiocytoses * to describe the value of chitotriosidase activity to screen this condition * to describe the value of various tissue biopsies in confirming the diagnosis * to describe the nature of polyvinylpyrrolidone accumulation in tissue macrophages by novel special microscopic techniques * to find new tandem mass spectrometry methodology to prove polyvinylpyrrolidone accumulation in macrophages * to show that polyvinylpyrrolidone treatment activates macrophages to histiocytes and causes povidone accumulation within the cells in in vitro experiments * to evaluate the pathology of macrophage activation to histiocytes by transcriptomics The patient history will be collected from the data produced by follow-up of cases followed up in a single center. A subgroup of participants will be given an opportunity to sign informed consent to give access to/donate blood and tissue samples to search for techniques to prove polyvinylpyrrolidone storage within histiocytes, and to search for transcriptomics signal(s) in histiocytes. Researchers will compare blood and tissue samples from the biobank as controls.
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
OBSERVATIONAL
Enrollment
30
Start Date
2023-05-29
Completion Date
2030-12-31
Last Updated
2025-09-10
Healthy Volunteers
Not specified
Conditions
Interventions
Chitotriosidase
The amount of patients with increased chitotriosidase, and the extent of elevation of chitotriosidase
Mass spectrometry
to show polyvinylpyrrolidone presence in histiocytes of injecting drug users compared to controls
scanning electron microscope with energy-dispersive X-ray spectroscopy
to show polyvinylpyrrolidone presence in histiocytes of injecting drug users compared to controls
Fluorescence microscopy
to show polyvinylpyrrolidone presence in histiocytes of injecting drug users compared to controls
Transcriptomics
To describe pathologic signals of polyvinylpyrrolidone-exposed in vitro histiocytes of injecting drug users compared to control samples
Locations (1)
Tampere University Hospital
Tampere, Pirkanmaa, Finland