Clinical Research Directory

Inclusion Criteria: * English-speaking * 50 years of age or older * Radiographically confirmed knee OA of K/L grade 2 or higher within the past 2 years * Knee pain at least 15 days/month. * Average worst daily pain 3/10 or higher over a two-week period. Exclusion Criteria: * Medical contraindication to taking NSAIDs such as: history of coronary artery bypass graft, myocardial infarction, coronary artery stent placement, or stroke within the past 6 months; systolic heart failure with ejection fraction \<45%; chronic kidney disease stage ≥4; severe gastrointestinal bleed or stomach ulcer within the past 6 months; current pregnancy; cirrhosis; currently taking blood thinners (aspirin 81 mg daily is okay); allergy to NSAIDs or aspirin; or any other medical contraindication to using topical NSAIDs. * Inflammatory arthritis * Partial or total knee replacement of the index knee * Recent therapeutic injection of the index knee (less than 12 weeks) * Planned knee/lower limb surgery during the two-month study period * Active cancer treatment not in remission or life expectancy less than 6 months * Inability to provide informed consent (e.g. dementia) * Current use of topical or oral NSAIDs more than 3 days per week. * Inability to receive text messages or emails to complete questionnaires between study visits. * Unable to follow the study protocol.