Clinical Research Directory

Inclusion Criteria: The main inclusion criteria include but are not limited to the following: All participants: * Has been a non-smoker or moderate smoker (≤ 10 cigarettes per day or equivalent) for at least 3 months prior to starting the study * Has body mass index (BMI) ≥ 18.0 and ≤ 40.0 kg/m2 Participants with moderate or mild HI: * Diagnosis of chronic (\> 6 months) and stable (no sudden or severe episodes of illness due to worsening liver function in the past 2 months) hepatic insufficiency, and features cirrhosis (liver scarring) due to any cause. * Is generally in good health with the exception of HI. Healthy Control Participants: * Medically healthy with no clinically significant medical history, physical examination, or clinical laboratory profiles Exclusion Criteria: The main exclusion criteria include but are not limited to the following: All participants: * History of gastrointestinal disease which may affect food and drug absorption, or has had a gastric bypass or similar surgery. * History of cancer * Consumes greater than 3 servings of alcoholic beverages per day. * Is on statin background therapy. Participants with moderate or mild HI: * Severe complications of liver disease within 3 months of entering the study.