Clinical Research Directory

Inclusion Criteria: * Patients scheduled for weight loss surgery (gastric sleeve procedure) * 40 years or older * PMH one or more of the following: 1. Diabetes Mellitus 2. Hypertension requiring medical treatment 3. Age \>65 years 4. History of HFpEF 5. Echocardiographic findings: left atrial enlargement (LAE), left ventricular hypertrophy (LVH), or right ventricular systolic pressure \>40 mmHg (RVSP) Exclusion Criteria: * Previous Bariatric surgery * Pregnancy * History of systolic heart failure, past or present LVEF of \<40% * Inability to perform exercise testing on a cycle ergometer (i.e. orthopedic conditions that preclude cycling or walking, recent systemic illness that compromises exercise capacity). * Any contraindication to performing exercise testing or any history of ventricular arrhythmia, any recent (within the last 3 months) or untreated supraventricular arrhythmia, elevated blood pressure at the time of presentation for exercise testing (\>155 mmHg systolic, or \>95 mmHg diastolic blood pressure), active or recent exacerbation of congestive heart failure, or history of reactive airways disease that is induced by exercise). * Acute myocardial infarction (3-5 days) or unstable angina * Uncontrolled symptomatic arrhythmias * Active endocarditis * Acute myocarditis or pericarditis * Symptomatic severe aortic stenosis * Acute pulmonary embolism or DVT * Suspected dissecting aneurysm * Uncontrolled asthma * Room air desaturation to \<85% * Acute non-cardiopulmonary disorder that may affect exercise performance (infection, orthopedic problem)